如果最低抑菌浓度为2，那么无论接受高剂量或低剂量的万古霉素，曲线下面积与最低浓度比值达标率概率，即药效学达标率概率，基本上为零。

 

And You can see the probability of AUC/ MIC attainment, the target attainment, is essentially zero, if MIC is 2 whether or not you receive high dose or low dose of vancomycin 

 

因此，从药代动力学和药效动力学角度来看，MIC值为2确实是一个问题。第二，有一些临床研究暗示如果病人的万古霉素MIC值为2，那么他们的万古霉素治疗失败机率增加北京翻译公司。

 

so from PK/PD perspective, MIC of 2 is really a problem. Secondly, there have been a number of clinical studies that suggest that patients who have vancomycin MIC of 2 have increased risk of vancomycin treatment failures.

 

所有这些研究是观察性研究，没有一项是随机研究，并且其中大部分研究是回顾性的，但是所有这些研究都得出相似结论：万古霉素的MIC值为2可能增加患者万古霉素治疗失败的危险韩语翻译。

 

All of these were observational studies and none were randomized studies, and most of them were retrospective, but they all came to similar conclusions that vancomycin MIC of 2 potentially increases one’s risk of treatment failure with vancomycin.